Neurobiology of Disease Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

نویسندگان

  • Ildiko Racz
  • Xavier Nadal
  • Judith Alferink
  • Josep E. Baños
  • Jennifer Rehnelt
  • Miquel Martín
  • Belén Pintado
  • Alfonso Gutierrez-Adan
  • Elena Sanguino
  • Jorge Manzanares
  • Andreas Zimmer
  • Rafael Maldonado
چکیده

Ildiko Racz,1* Xavier Nadal,3* Judith Alferink,1,2* Josep E. Baños,3 Jennifer Rehnelt,1 Miquel Martín,3 Belén Pintado,4 Alfonso Gutierrez-Adan,4 Elena Sanguino,5 Jorge Manzanares,5 Andreas Zimmer,1 and Rafael Maldonado3 1Institute of Molecular Psychiatry and 2Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, 3Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, 08003 Barcelona, Spain, 4Departamento de Reproducción Animal y Conservación de Recursos Zoogenéticos, Instituto Nacional de Investigación y Tecnología Agraria, 28040 Madrid, Spain, and 5Instituto de Neurociencias de Alicante, Universidad Miguel Hernández–Consejo Superior de Investigaciones Científicas, 03550 Alicante, Spain

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processing of pain is crucial for the identification of novel analgesic targets/new therapeutic strategies. Inhibitory cannabino...

متن کامل

بررسی اثر سیستم کانابینوییدی اندوژن بر عملکرد عصبی بافت کورپوس کاورنوزوم دستگاه تناسلی خارجی موشهای صحرایی نر

    Background & Aim: Although studies have shown the central effects of Endocannabinoid on erection, its' peripheral effect is unknown. The purpose of this study was to investigate the effect of the endogenous cannabinoid anandamide on the nonadrenergic noncholinergic(NANC) relaxant responses to electrical field stimulation in isolated rat corpus cavernosum, a crucial tissue in erectile functi...

متن کامل

Effect of Cannabinoid Receptor Activation on Spreading Depression

Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...

متن کامل

Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post-ischemic pain model of complex regional pain syndrome type I in rats.

Complex regional pain syndrome type 1 (CRPS-I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully characterized. Cannabinoid receptor 2 (CB2) has emerged as a promising target for treating different neuropathic pain syndromes. In neuropathic pain models, activated microglia expressing CB2 receptors are seen in the spinal cord. Chemokin...

متن کامل

Methods for recombinant expression and functional characterization of human cannabinoid receptor CB2

Cannabinoid receptor CB2 is a seven transmembrane-domain integral membrane protein that belongs to a large superfamily of G protein-coupled receptors (GPCR). CB2 is a part of the endocannabinoid system that plays vital role in regulation of immune response, inflammation, pain sensitivity, obesity and other physiological responses. Information about the structure and mechanisms of functioning of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008